The main aim of this research was to develop a new method for voltammetric determination of popular antidepressants, analgesics, and illicit drugs using a laboratory-made 3D printed electrode and to compare the achieved results with those registered using a commercially available glassy carbon electrode. These experiments represent the first step in the development of a method applicable in clinical and forensic praxis for the rapid and inexpensive determination of commonly misused groups of biologically active compounds.