Publikace na Přírodovědecká fakulta, Fakulta tělesné výchovy a sportu |
2021
Abstrakt
Terconazole is a widely used antimycotic. Terconazole belongs to the second generation of triazole fungicide with a 1,2,4-triazole ring, which is known to block ergosterol biosynthesis of fungi.
On the other hand, its effect in the presence of potentially interfering compounds is not explored. In the gas phase experiments, we provide the reaction simulation between terconazole and copper (II) using ESI-MS.
Terconazole in presence of copper(II) became oxidized. The direct oxidation of a triazole in the gas phase wasn't observed before.
This result indicates that terconazole is potentially highly reactive (even electrochemically) and therefore its reaction has to be further investigated.