Abstrakt
During forced degradation studies that are a part of the drug product development, an active substance is exposed to extreme conditions. The effect of humidity, light, pH and oxidation on the active substance is studied.
The most common way to study the effect of oxidation is to expose active substance to a 0.1-3.0% solution of hydrogen peroxide. Another possibility is to use radical initiators or metal ions.
An alternative method is electrochemical oxidation. The oxidation of an active substance is not only affected by the oxidation agent but also depends on the solvent.
In this study, the abacavir oxidation in different solvents by different approaches is investigated. The electrochemical oxidation in flow cell was compared with peroxide mediated, radical and metal ions oxidation.
Electrochemical oxidation yielded the largest variety of oxidation products from all the tested approaches.