Publication at Third Faculty of Medicine |
2022
Abstract
The SARS-CoV-2 infection can induce an excessive production of pro-inflammatory cytokines causing the cytokine storm syndrome. The uncontrolled nonspecific immune response and the specific immune response impairment induced by SARS-CoV-2 eventually result in the tissue damage.
Understanding the mechanisms of non-specific and specific immunity induced by SARS-CoV-2 is essential to be able to predict the disease outcome and to develop effective strategies to control the virus spread. Reactions of the immune systém and the key immunopathogenetic mechanisms involved in covid-19 disease are discussed.