Publication at Faculty of Medicine in Hradec Králové |
2022
Abstract
Causes of mental disorders are complex. Both genetic (single nucleotide polymorphisms, copy number variations, epistasis) and environmental (biological, psychological, social, spiritual) factors participate in their etiology.
Epigenetics frequently plays an important role in gene-environment interactions. This review sums up the basic knowledge on general principles in etiology of mental disorders.
New DNA sequencing techniques including innovative statistical procedures, validation and quantification of environmental factors, creation of international multicentric research consortia or seeking of protective factors in etiology of mental disorders belong to recent trends.