Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma

Abstract

Identifying patients with an increased risk of early recurrence of colorectal lesions is still a problem. In our study, we focused on improving this identification by determining the mutation profile of index lesions.

We found a statistically significant association between the mutation in exon 7 of the TP53 gene in the index lesion and the risk of early metachronous adenoma.

Keywords

• colorectal cancer
• colorectal adenomas
• colonoscopy
• index lesion
• synchronous lesion
• metachronous lesion
• tumor heterogeneity
• TP53