Rheumatoid arthritis is a chronic autoimmune disease that affects inflammation of the peripheral joints, but often also the extra-articular tissues, including the skin. Rheumatoid nodules are among the relatively common specific skin manifestations, and rheumatoid vasculitis may also occur rarely.
Uncommon include some granulomatous skin diseases and neutrophilic dermatoses. Traditional, biological and targeted synthetic drugs can result in skin side effects, which in many cases present diagnostic embarrassment and therapeutic difficulties.
This review article will discuss selected specific and non-specific skin manifestations, including rare and undesirable dermatological effects associated with antirheumatic treatment.