Optimal Alzheimer's disease detection and diagnosis under the sex and gender lens: a crucial step towards precision neurology

Abstract

Alzheimer's disease pathophysiology emerges decades before the first clinical signs and symptoms appear. The clinical continuum of the disease is therefore characterised by a long asymptomatic, preclinical stage and a complex trajectory.

It is important to detect the first biological indicators and diagnose affected individuals as early as possible, to effectively implement secondary preventative strategies, to provide access to potential (pharmacological and non-pharmacological) disease-modifying treatments, and to allow individuals and their families to plan for the future.