Fasciculations are one of the uncommon but potentially serious neurological symptoms and can occur in a variety of neurological and other diseases or conditions. They can arise for many different reasons: from metabolic-endocrine (calcium and magnesium metabolism disorder, hyperthyroidism), through drug side effects (succinylcholine, depolarizing muscle relaxants, acetylcholin inhibitors, salbutamol) to serious neurological diseases (ALS/MND, neuropathy, root syndromes, borreliosis).
They are often the result of increased neuromuscular irritability during excessive use of stimulants (caffeine, tein) or increased anxiety, or after sudden physical overload. If the condition is persistent and we are unable to find the cause of the fasciculations, then the finding can be described as a benign fasciculation syndrome that has a good prognosis.