Patients with psoriasis suffer from a variety of comorbidities, arising from both direct and indirect causes. These comorbidities are very heterogeneous, ranging from metabolic, to cardiovascular, to other autoimmune diseases.
Some comorbidities may also be drug-induced. Therefore, the choice of systemic therapy, including biologic therapy, must take into account possible comorbidities, especially because of possible contraindications or, conversely, possible common therapeutic use