Publikace na Matematicko-fyzikální fakulta |
2022
Abstrakt
Guanosine-5'-monophosphate (5'-GMP) tends to self-associate at higher concentrations and forms regular order arrangements G-quartets and further G-quadruplexes. These associates have been thoroughly studied and have possible applications both in bionanotechnology and medical treatment.
We study 5'-GMP associates using Raman spectroscopy and its chirally sensitive variant Raman optical activity (ROA). ROA appears to be very sensitive to the aggregation process reflected in significant spectral changes.