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Raman optical activity as a potent tool for studies of mononucleotide G-quadruplexes

Publication at Faculty of Mathematics and Physics |
2022

Abstract

Guanosine-5'-monophosphate (5'-GMP) tends to self-associate at higher concentrations and forms regular order arrangements G-quartets and further G-quadruplexes. These associates have been thoroughly studied and have possible applications both in bionanotechnology and medical treatment.

We study 5'-GMP associates using Raman spectroscopy and its chirally sensitive variant Raman optical activity (ROA). ROA appears to be very sensitive to the aggregation process reflected in significant spectral changes.