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First-line treatment for non-squamous NSCLC without driver mutations

Publication at Third Faculty of Medicine |
2022

Abstract

Immunotherapy in monotherapy or in combination with chemotherapy dominates the first-line treatment of non-small cell lung cancer. There are several reimbursed treatment regimens available.

For treatment selection, patient performance status and PD-L1 expression are important. In patients, in which immunotherapy is contraindicated due to comorbidities or poor performance status, platinum-based chemotherapy in combination preferably with pemetrexed or bevacizumab is indicated.

The following text summarizes recent findings from clinical trials and recommended treatment.