Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men

Abstract

Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion - independent of insulin action.

We thus hypothesized exogenous GLP-1 infusions would enhance muscle perfusion and positively impact glucose metabolism during fed-state clamps in older people.

Keywords

• Glucagon like peptide 1
• extrapancreatic effects
• muscle glucose uptake
• muscle glucose metabolism
• microvascular blood flow
• microvascular recruitment
• microcirculation