Annulated carbamates are precursors for the ring contraction of the adamantane framework

Abstract

We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines. The first step is the triflic acid-promoted decarboxylation of adamantane carbamates, which causes rearrangement of the adamantane framework to form noradamantane iminium salts, which are reduced to amines in the second separate step.

Keywords

• discovery
• aldehydes
• access
• carbamates
• adamantane framework