Abstract
Nonsteroidal antiinflammatory drugs (NSAIDs) exacerbated respiratory disease is characterized by severe bronchial asthma, hypersensitivity to nonsteroidal antiinflammatory drugs and chronic rhinosinusitis with nasal polyps. The important role is overproduction of cysteinyl leukotriene.
The exact mechanism of pathogenesis in respiratory disease exacerbated by NSAIDs is not fully understood, recent studies have shown the importance of other cells and molecules and related advances in therapy. The management involves guideline - based treatments for asthma and chronic rhinosinusitis and avoiding acetylsalicylic acid and all medications that inhibit cyclooxygenase 1.
There have been several important advances in the management of asthma and nasal polyps which have the potential to change the treatment paradigm in the management of NSAIDs-exacerbated respiratory disease.