Effectiveness and Safety of High-Dose Dual Therapy: Results of the European Registry on Helicobacter Pylori Management (HP-EUREG)
Abstract
Introduction: Randomized clinical trials and meta-analyses, primarily from Asian countries, have reported good effectiveness with high-dose dual therapy (HDDT, i.e., PPIs plus high amoxicillin doses) when prescribed for H. pylori first-line or rescue treatment. However, combining amoxicillin with PPIs in the 1990s in several European countries yielded suboptimal results.
The objective was to analyse the effectiveness, compliance and safety of HDDTin the European real clinical practice.