Experimental surgery as part of the development of degradable biomaterials for cardiovascular surgery
Abstract
Cardiovascular diseases are responsible for significant morbidity and mortality in the population. preclinical testing of each new material is imperative, both in vitro and in vivo, and therefore animal experiments are still a necessary part of the testing process before any clinical use. The aim of this paper is to present the options of using various experimental animal models in the field of cardiovascular surgery including their extrapolation to clinical medicine.
An in vivo experiment cannot be avoided in the last phases of cprelinical research of new materials. However, we try to strictly observe the 3R concept - Replacement, Reduction and Refinement; in line with this concept, the potential of each animal should be used as much as possible to reduce the number of animals.