Inflammation in axSpA AS A disruptor of bone metabolism - the effect of patients' sera on an in vitro bone model

Abstrakt

Data acquired from the in vitro bone model point to an imbalance in the enzymatic activity of osteoclasts and to changes in the metabolic activity and proliferation of both, osteoblasts and osteoclasts. These changes seem to be caused by inflammatory agents in patients' sera.

However, the changes are not the same in both forms of disease, which may explain differences between nr- and r-axSpA symptoms.