Abstract
Dimetindene is a sedative antihistamine indicated for the symptomatic treatment of cough, common cold and urticaria in children. Toxicity data are very limited and there is no consensus on the dose at which children require hospitalization.
According to inquiries to Toxicology Information Center (TIC) in the years 2010- 2022, the children were intoxicated in 95% of cases, adults in only a fraction of cases (5%). The number of consultations is increasing.
In a study of 100 discharge reports from hospitalizations of children in 2020-2022, it was found that up to a dose of 0.25 mg/kg of body weight, children were asymptomatic, and up to a dose of 0.50 mg/kg, only mild symptoms occurred. In 98% of cases, the children were hospitalized for a maximum of 24 hours and their condition did not require treatment.
According to these preliminary results, the prognosis of accidental dimetinden intoxications in children appears to be good. However, if a dose of 0.50 mg/kg is exceeded or in case of doubt, we recommend always consulting TIC.