Abstrakt
The rapid emergence of resistant bacteria highlights the urgent demand for new effective drugs. In view of the importance of adamantane skeleton in various antimicrobial drugs, herein the synthesis of N-adamantane-1-carboxamides of polyamine derivatives is described.
The in vitro antibacterial activity of the new synthesized compounds against two Gram-positive (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, as well as the antifungal activity against Candida albicans was assessed. The results revealed that amongst the new synthesized bisamides, N,N'-bis-adamantane-1-carboxamide of 1,6-diaminohexane was the most effective one and inhibited both Gram-negative and Gram-positive strains with MIC of 125 μg.ml(-1).
Moreover, the same amide showed the highest antifungal activity (MIC of 63 μg.ml(-1)) against Candida albicans.