Charles Explorer logo
🇨🇿

Microdeletions of the Y Chromosome in Czech Males with Serious Reproductive Disorders

Publikace na 1. lékařská fakulta, Fakulta tělesné výchovy a sportu, 2. lékařská fakulta |
2003

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

Background. The Y chromosome microdeletions belong to the frequent genetical causes of male infertility.

The aim of our study was to introduce reliable molecular genetic diagnosis of Y chromosomal microdeletions and to determine the prevalence of Y chromosomal microdeletions in Czech males with serious reproductive disorders. Methods and Results.

The Y chromosome microdeletions were screened in 198 Czech men with serious reproductive disorders with decreased sperm count. The Y chromosome microdeletions were disclosed in 8/198 (4.0 %) examined males.

The AZFc deletion type was revealed in 62,5 % (5/8) and the combined AZFc+b microdeletion in 37,5 % (3/8) of cases. Neither isolated AZFb nor AZFa microdeletion were found in any subject of the investigated group.

Conclusions. Incidence of individual types of Y chromosomal microdeletions in Czech males with serious reproductive disorders was assessed.

The standardised molecular genetic diagnosis of Y chromosomal microdeletions was introduced into the practice.