Eicosanoids in human heart failure: pilot study of plasma epoxyeicosatrienoic and dihydroxyeicosatrienoic acid levels
2023
Abstract
INTRODUCTION: The role of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, remains unclear in human heart failure (HF). METHODS: We enrolled 50 patients with HF to measure plasma 14,15-EET and 14,15-DHET levels using commercial ELISA kits and compared them with 25 age- and sex-matched controls.
RESULTS: Both of the measured eicosanoids were significantly higher in the HF group: 14,15-EET (91.3 +-25.7 ng/ml vs. 64.95 +-35.4 ng/ml) and 14,15-DHET (10.58 +-2.06 ng/ml vs. 9.07 +-1.60 ng/ml), p for both < 0.001. CONCLUSIONS: We found that peripheral plasma eicosanoid (14,15-EET, 14,15-DHET) levels are raised in patients with HF compared to age- and sex-matched controls.