Charles Explorer logo
🇨🇿

The buffer power of plasma proteins: experimental observations are consistent while the definitions are not

Publikace na 3. lékařská fakulta |
2023

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

We read with interest the paper by Matthew B.Wolf and congratulate the author on further improvement of his multicompartment model of acid-base equilibrium. In this paper, the author discusses two seemingly contradictory findings.

The first is an association between low albumin con-centration and enhanced buffering against PCO2, expressed as dPCO2/d[Hþ], in plasma-like solutions. The other is a positive correlation between albumin concentration and buffering ability, expressed as d[HCO3]/dpH, in normo- and hypoal-buminemic plasma samples.

In this letter, we would like to demonstrate that these data are not contradictory.