Publikace na 1. lékařská fakulta |
2023
Abstrakt
In late February, 2023, some sublineages of the SARS-CoV-2 omicron XBB variant harbouring the F486P substitution in the spike protein (eg, XBB.1.5 and XBB.1.9) predominated worldwide, according to Nextstrain. XBB.1.16, an XBB sublineage that also harbours the F486P substitution, has been subsequently detected in various countries.
XBB.1.16 emerged independently from XBB.1.5. Compared with XBB.1.5, XBB.1.16 has two substitutions in the spike protein: E180V in the N-terminal domain and T478R in the receptor-binding domain.
XBB.1.16 outcompeted other variants in India by the end of March, 2023. Notably, XBB.1.16's effective reproductive number (Re) in India was 1.22-fold higher than the parental XBB.1 and 1.13-fold higher than XBB.1.5.