Abstract
Virtually since its inception, hypertrophic cardiomyopathy (HCM) has been regarded as a genetically transmitted disease, often demonstrating an autosomal dominant pattern of inheritance, and supported by the monogenic sarcomere mutation hypothesis This construct has been promoted universally for HCM with respect to both disease cause and transmission of clinically overt phenotype within families. The principle that HCM can occur in families and be responsible for heart failure disability or arrhythmic sudden death often serves as a source of both anxiety and guilt on the part of families