Abstrakt
The cardiac sympathetic nervous system plays an important role in the regulation of cardiac functions, such as increasing heart rate, myocardial contraction and conduction velocity. We evaluated how the diabetic environment in combination with HIF-1α dysregulation affects the cardiac sympathetic system and heart function.
Our results show that the diabetes leads to the reduction of sympathetic innervation in the hearts of Hif1aCKO mice; the branching and thickness of innervation, together with the density of sympathetic neurons are affected. We demonstrate that the elimination of Hif1a in the sympathetic nervous system in combination with diabetes results in the altered transcriptome, compromised cardiac innervation, worsened heart function, and adverse myocardial remodeling.