Abstract
Breast cancer in young women (YBC) is often associated with aggressive histology and a higher stage of the disease at the time of diagnosis. Triple-negative breast cancer (TNBC), the presence of a hereditary mutations, concerns about chemotherapy-induced amenorrhoea and/or concerns about prognosis are key words in the treatment of patients with YBC.
However, current data have not shown a superiority of a particular type of systemic treatment or local methods of therapy tied to a population of patients under 40 years of age with TNBC. Also, the prognosis of TNBC in patients with YBC does not differ significantly from that of older women with TNBC.
This is mainly due to the chemosensitive basal-like subtype, which predominates in young patients with TNBC. The prognosis of TNBC is further improved by the availability of treatments, in particular immunotherapy (IO) and/or PARP (poly (ADP-ribose) polymerase inhibitors.