Abstrakt
Zimmermann-Laband syndrome is a rare genetic disorder. Patients show multiple phenotypic abnormalities, including skeletal abnormalities of fingers and toes and hypoplasia or aplasia of nails.
We studied a pair of monozygotic twins with this syndrome, confirmed at the molecular level, and performed a dermatoglyphic analysis. The analysis showed unusually simple patterning on all fingertips of both individuals: all patterns were arches.
There were additional anomalies on the palms. The observed anomalies most likely reflect disharmony in the development of mesodermal structures of the hand caused by the syndrome.
Because dermatoglyphs are complex traits, more research is warranted to unravel the relationship between involved genes and palmar patterns.