Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL

Abstrakt

We studied the impact of JAK2 fusions on metabolic rewiring of leukemic cells; we chose two representatives, the most frequent fusion and a novel previously undescribed fusion, and we showed that JAK2 fusions indeed alter energy metabolism of leukemic cells, but surprisingly in a very distinct manner.

Klíčová slova

• Chimeric JAK2
• Cellular Metabolism
• BCR-ABL1-like Childhood ALL