Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL

Publication at Central Library of Charles University, Second Faculty of Medicine |

2023

Abstract

We studied the impact of JAK2 fusions on metabolic rewiring of leukemic cells; we chose two representatives, the most frequent fusion and a novel previously undescribed fusion, and we showed that JAK2 fusions indeed alter energy metabolism of leukemic cells, but surprisingly in a very distinct manner.

Keywords

Chimeric JAK2 Cellular Metabolism BCR-ABL1-like Childhood ALL

Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL

Abstract

Keywords

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