En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies

Abstract

We report the preparation, characterisation and in vitro tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot.

Keywords

• local glioblastoma
• Brain tumours
• central nervous system
• hyaluronan fibre