Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman-O'Connell-Griffin Rearrangement

Abstract

A photomediated protocol giving facile access to substituted β-lactam and β-lactones is presented. The method realizes, for the first time, the use of the Zimmerman-O'Connell-Griffin (ZOG) rearrangement in [2 + 2] cycloaddition.

Products are obtained in high yield with excellent diastereoselectivity under visible light irradiation and under mild reaction conditions.

Keywords

• LASER FLASH-PHOTOLYSIS
• TRANSFORMATIONS
• STATE