Baseline immunophenotypic profile of bone marrow leukemia cells in acute myeloid leukemia with nucleophosmin-1 gene mutation: a EuroFlow study
2023
Abstract
In summary, the mutational status of NPM1 and FLT3 is associated with unique BM leukemia cell distribution and immunophenotypic profiles, even when only cases with a normal karyotype were considered (data not shown), which might contribute to a fast diagnostic screening of NPM1mut and/or FLT3-ITD in AML, and an improved classification of AML-NPM1mut patients. Further prospective studies are needed to confirm these findings.