Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest : A Predefined Analysis of the TTM2 Randomized Clinical Trial

Abstract

Question: Is there an effect of targeted hypothermia vs targeted normothermia on functional outcome focusing on societal participation and cognitive function in survivors 6 months after out-of-hospital cardiac arrest? Findings: In this predefined analysis of a randomized clinical trial, limitations in societal participation and cognitive impairment were common 6 months after out-of-hospital cardiac arrest with no differences between the 2 intervention groups. Younger survivors reported more limitations in societal participation.

Meaning: In this study, targeted hypothermia had no significant effect on societal participation or cognitive function compared with targeted normothermia at 6 months in survivors of out-of-hospital cardiac arrest.

Keywords

• hypothermia
• normothermia
• societal participation
• cognitive function
• out-of-hospital cardiac arrest