Publication at Faculty of Mathematics and Physics |
2023
Abstract
Molecular self-assembly of nucleotides and their oligo- and poly- forms is a prevalent phenomenon that establishes the structural and functional framework within living cells. Among mononucleotides, Guanosine 5'-monophosphate (5'-GMP) and its derivates exhibit a remarkable ability to form distinct structures at higher concentrations.
Initially, 5'-GMP molecules associate to form G-quartets1 through hydrogen bonding which subsequently stack to generate ordered structures known as G-quadruplexes (G4). The stability of G4 structures arises from various factors, including Hoogsteen base pairing, stacking, hydrophobic interactions, cation coordination, and hydrogen bonds between adjacent mononucleotide phosphate and hydroxyl groups.