Publication at First Faculty of Medicine |
2023
Abstract
The Czech alpha-1 antitrypsin deficiency (AATD) registry collects relevant clinical data on subjects with severe genotypes. This study presents analysis of smoking as a risk factor for clinical presentation of COPD in severe AATD.
The study results show that severe AATD is not necessarily accompanied by the development of COPD, with approximately one quarter of subjects being free from any respiratory disorder when entered into the registry. In comparison with smokers, the clinical presentation of COPD is delayed by approximately 20 years in lifelong nonsmokers.
Thus, smoking abstinence remains the main preventive and treatment modality in AATD.