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Drug induced angioedema

Publication at Faculty of Medicine in Hradec Králové |
2023

Abstract

Drug-induced angioedema is a potentially life-threatening adverse drug reaction. Angioedema of bradykinin origin constitutes a significant percentage pathogenetically.

Its most common cause is angiotensin-converting enzyme inhibitors administered to predisposed individuals. Anamnesis plays a key role in diagnosis.

Laboratory tests are usually not beneficial. In the acute phase, the basic treatment procedure is to ensure free airways, as the administration of corticosteroids and antihistamines is not effective.

In the long term, a change in medication is necessary. Other risky drugs include sartans, sacubitril valsartan, aliskiren, gliptins, mTOR inhibitors or tissue plasminogen activator.