The potential of exome sequencing of paired colorectal tumors and synchronous liver metastases to improve treatment

Abstrakt

Sequencing exomes of synchronous and metachronous liver metastases of colorectal cancer has potential to enhance treatment, since they can have molecular profiles distinct from primary tumors.

Klíčová slova

• colorectal cancer
• exome
• KRAS
• liver metastasis
• metachronous
• next-generation sequencing
• personalized therapy
• prognosis
• progression
• synchronous