Abstract
Type 2 diabetes mellitus entails an increase in the cardiovascular risk of patients. In addition to type 2 diabetes, patients often have a number of risk factors and comorbidities, especially overweight, hypertension, dyslipidaemia, and other disorders.
Therefore, the preferred treatment even in the early phase of the disease includes antidiabetic drugs with a complex effect and that are proven cardio-protective, such as GLP-1 receptor analogues (GLP-1RA). The combination of GLP-1RA and metformin is advantageous at the beginning of the treatment.
However, this strategy may only be effective temporarily for some patients. The presented case report documents a possible method of treatment intensification, if the combination of GLP-1RA and metformin is not sufficient to maintain normoglycaemia.