Abstract
Humans are commonly and regularly exposed to bisphenols, but their cardiovascular effects were ambiguous or not know due to absence of studies. The aim of this study was to test 14 bisphenols (A, AF, AP, B, BP, C, E, F, G, M, P, PH, S and Z), and compare their effects in vitro (human and rat cell lines), ex vivo (isolated rat aorta) and in vivo (Wistar Han rats, acutely or chronically exposed to low environmental and high toxic doses).
The majority of the tested bisphenols relaxed rat aorta, but their potency varied markedly. The mechanism of action was likely based on the inhibition of calcium influx via L-type calcium channels.
The cytotoxicity of bisphenols towards cell lines showed variable potencies. The in vivo acute effects of three doses (0.005, 0.05 and 2.5 mg/kg) of bisphenol AF and 3 other analogues (A, S and F) on the cardiovascular system were, however, rather biologically negligible.
The most potent bisphenol, AF, administered chronically had also no impact on arterial blood pressure.