Abstract
The theory of movement of charged particles in solutions is based on fundamental physico-chemical equations, which form an inherently nonlinear mathematical model. An alternate approach is the formulation of the approximate linear model for capillary zone electrophoresis.
The nonlinear and linear models of electromigration are implemented in two computer programs we have developed, Simul and PeakMaster, respectively. Both of them serve for method development in electromigration separation methods.
PeakMaster is based on the linear model and was designed for the computer optimization of back-ground electrolytes for capillary zone electrophoresis to reach higher efficiency and better selectivity of separation. Simul is based on the numerical solution of the nonlinear mathematical model of electro-migration and serves mainly for inspecting disturbing phenomena in electromigration.
Both PeakMaster and Simul in version 6 have been launched as free software available for download at https://echmet.natur.cuni.cz/.