The changes in the faecal microbiome and metabolome in Crohn's disease after treatment with anti-TNF(sic) antibodies are of secondary origin
Abstract
Treatment by anti-TNFα antibodies (aTNFα) is known to change the dysbiotic faecal bacteriome in Crohn's disease (CD). However, whether the change is caused by aTNFα itself or by improv- ing the gut inflammation status is unknown.
Therefore, we aimed to identify and compare bacterial taxa and faecal metabolite changes upon aTNFα between children with CD and juvenile idiopathic arth-ritis (JIA), a disease very rarely affecting the gut.