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The differences in the count of B lymphocytes in atopic dermatitis patients with and without dupilumab therapy and in healthy subjects in pollen season and out of pollen season

Publication at Faculty of Medicine in Hradec Králové |
2024

Abstract

The aim of the study is to measure the absolute count of leukocytes, lymphocytes, absolute B lymphocytes, relative count of B lymphocytes with their subsets and the count of DC5+, CD22+ and CD73+ B lymphocytes in atopic dermatitis patients in pollen season and out of pollen season nad compare in with these counts in healthy subjects. We examined two grups of AD patients; patients withoutdupilumab treatment (21 patients - 6 men, 15 women, age 36,2 years) and patients treated with dupilumab (13 patients - 7 men, 6 women, age 43,4 yers).

Laboratory test to determine the parameters of interest were performed in these patients during the pollen season (June-August) and outside the pollenseason (October-February). In pollen season, the count of toptal memory B lymphocytes is significantly lower the countof naive B lymphocytes is significantly higher in both controls and AD patients compared to the cont out of pollen season.

Out of pollen season we the lower count of relative CD22 B lymphocytes in both groups of AD patients compared controls. Significant changes occur also in healthy subjeckts in pollen season in the count of memory, naive and non switched B lymphocytes.