Charles Explorer logo

PPY-cell hyperplasia accompanying NENs: Immunohistochemical and nuclear medicine analysis

Publication at Third Faculty of Medicine |


Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of the neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H and its corresponding clinical and imaging findings still need to be fully elucidated.

We present 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN). PPY-H was analyzed with the help of immunohistochemistry and confocal microscopy; preoperative clinical data and imaging studies were evaluated retrospectively.

We observed PPY-H emerging from pancreatic ducts, and in some cases, we observed simultaneous NKX6.1 positivity in ducts and PPY-H. Additional clinical-pathological correlations suggests that gastrointestinal symptoms (e.g., epigastric pain and cholestasis) could be more related to PPY-H than to NEN hormonal production.

In particular cases, SSTR2 expression was strong in PPY-H and correlated with distinguishable accumulation of activity next to NEN on (99 m)Tc EDDA/Hynic-TOC SPECT/CT. In another case, (18)F-FDG-PET/CT showed increased metabolic activity in the area of PPY-H surrounding NEN.

Our data suggest that PPY-H originates in the lining of pancreatic ducts. Confirmation of SSTR2 in PPY-H, using immunohistochemistry, suggests the utility of (99 m)Tc EDDA/Hynic-TOC or (68)Ga-DOTA radiotracers in clinical diagnostics; however, studies with larger cohort are needed.