Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response

Abstract

In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.

Keywords

• onset colorectal-cancer
• mismatch repair
• prevalence
• chemotherapy
• efficacy
• outcomes
• impact
• colon
• age