Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
2023
Abstract
Background Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progression may be affected by urate-lowering treatment (ULT). Our study aimed to evaluate differences in plasma lipidome between patients with asymptomatic HUA detected 40 years, gout patients with disease onset 40 years, and normouricemic healthy controls (HC).
Methods Plasma samples were collected from 94 asymptomatic HUA (77% HUA 95%. Conclusion Alterations in the lipidome of HUA and Gout patients show a significant impact on lipid metabolism.
The most significant glycerophospholipid dysregulation was found in HUA <= 40 and Gout <= 40 patients, together with a correction of this imbalance with ULT.