Abstract
Derivatives of acridine, preferably substituted with a carboxamide group bearing a group containing a carbon chain terminated with a base function, substituted with a carbon chain in the form of an alkynyl terminated with an azido group serving to covalently bind, for example, to an oligonucleotide probe. The modification of the core serves to fix the binding to the DNA double helix by means of hydrogen bonding with nitrogen and oxygen of the guanine, then by means of hydrogen bonding of an amide hydrogen via a water molecule to a phosphate group between the corresponding guanosine and the adjacent nucleoside.
The azido group used for azido-alkyne cycloaddition to a suitably modified chain of an exemplary oligonucleotide.