The novel iron chelator, 2-pyridylcarboxaldehyde-2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity

Abstrakt

Two iron chelators - deferoxamine and 2-pyridylcarboxaldehyde-2-thiophenecarboxyl hydrazone (PCTH) - were tested on isoprenaline model of myocardial toxicity. Deferoxamine was not efficient while PCTH reduced some markers of cardiac injury.

Klíčová slova

• isoprenaline
• iron chelators
• myocardial toxicity
• PCTH
• deferoxamine