Publication at First Faculty of Medicine |
2009
Abstract
Monoclonal gammopathy of undetermined significance (MGUS) is precancerosis mainly of multiple myeloma (MM). Project MGUS 2010 is the first project generated from Register of Monoclonal Gammopathy (RMG; activated in 2007) of Czech Myeloma Group, myeloma section of Czech Hematology Society respectively.
Main aims of this project are: to find biological (genomic/proteomic/cytomic) markers of progression from MGUS to MM; to stop progression form high risk MGUS to MM using experimental therapy; to inform precisely people with MGUS about risk of progression. Creation of a new model superior to currently used systems for the identification of high-risk MGUS patients is the target outcome of this international project.